Immune Surveillance For Cancer: How It Works Or Does Not Work.

Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment resistant, immune-invisible recurrences has major clinical significance. We show here that this transition is mediated through the subversion of two key elements of innate immune surveillance. … Continue reading

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40% of workers in Canada suffer from depression Ipsos study.

by David Keelaghan  13 Oct 2017 Depression and mental illness is affecting a significant amount of Canadian workers, reveals a new survey from Ipsos. The study, commissioned by the Great-West Life Centre for Mental Health in the Workplace, shows that four out … Continue reading

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What If Canada Had A $20 Per Visit User Fee?

The revenue potential from even small user fees is substantial. Recent research has calculated that, if in the fiscal year 2004-2005 provincial/territorial governments had pegged all future increases in physician fee-for-service payments to changes in the CPI and allowed extra … Continue reading

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Lost in Thought — The Limits of the Human Mind and the Future of Medicine – NEJM.

Authors; Ziad Obermeyer, M.D., and Thomas H. Lee, M.D. N Engl J Med 2017; 377:1209-1211September 28, 2017 In the good old days, clinicians thought in groups; “rounding,” whether on the wards or in the radiology reading room, was a chance … Continue reading

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Patient in vegetative state for 15 years improves with vagus nerve stimulator: Raymond Rupert MD, MBA

It is reported in Current Biology: Volume 27, Issue 18, pR994–R996, 25 September 2017 Following the theory that vagus nerve stimulation functionally reorganizes the thalamo-cortical network, we tested its effects on the cortical activity of a patient lying in a vegetative … Continue reading

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With Mental Health In The Workplace- Where Does A Company’s Responsibility Start Or Stop? Raymond Rupert MD, MBA.

An Occupational Health Case Study:  We got a call from an employment lawyer representing his client. The client was a large veterinary clinic. An employee at the clinic who is an animal handler had spoken to co-workers about this thoughts … Continue reading

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What Healthcare Can Learn About Quality From Lamborghini: Raymond Rupert MD, MBA.

This story tells us what it takes to be “world class” in the delivery of quality and outcomes. Healthcare is similar to luxury auto manufacturing. Both are one off businesses. Creating solutions one at a time. Healthcare has much to … Continue reading

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What a devoted father did to help his daughter avoid brain surgery: Raymond Rupert MD, MBA.

Our goal at Rupert Case Management is to help families access world class solutions for complex health problems. This is not a trivial exercise. Choosing the right solution requires extensive investigation into the global ecosystem of advanced treatment options. To … Continue reading

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How Much Does It Cost To Develop A New Cancer Drug? Try $648,000,000. Ed Silverman Pharmalot.

How much does it cost to develop a cancer drug? A new analysis finds the magic number is $648 million, which is substantially less than an earlier — albeit controversial — estimate of $2.6 billion for the cost to develop … Continue reading

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Nature Heals- Rebecca Lawton in Aeon Magazine.

The longer the trip, the more healing occurs,’ says the geologist Peter Winn, who has been leading expeditions down the Colorado River in the Grand Canyon since the 1960s. ‘Healing happens for people almost without exception.’ The most dramatic transformations … Continue reading

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