Monthly Archives: November 2016

Overall Survival in Many Cancer Drug Trials Provides Marginal Versus Real Improvements:

Sham Mailankody, MB, BS1; Vinay Prasad, MD, MPH2,3 Author Affiliations JAMA Oncol. Published online November 17, 2016. doi:10.1001/jamaoncol.2016.5296 Cancer regulatory approvals aim to permit drugs to be marketed to improve survival or quality of life for patients. Approximately one-third of cancer drugs approved come … Continue reading

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CRISPR GENE EDITING USED FOR FIRST TIME TO FIGHT LUNG CANCER: Raymond Rupert MD. MBA.

A Chinese group has become the first to inject a person with cells that contain genes edited using the revolutionary CRISPR–Cas9 technique. On 28 October, a team led by oncologist Lu You at Sichuan University in Chengdu delivered the modified … Continue reading

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BIG PHARMA AND HIGH COST BIOLOGICS: Raymond Rupert MD, MBA.

Sovaldi is a new biologic produced by Gilead Sciences to treat and cure hepatitis C. The cost for 2 months of treatment with Sovaldi in Egypt is $800. In Canada, Sovaldi costs $55,000. Gilead has a solid hold on the … Continue reading

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One brain, many genomes : Gilad D. Evrony MD, PhD. Mass General and MIT

While in the laboratory of Christopher Walsh at Boston Children’s Hospital and Harvard Medical School, I became intrigued by reports of neurologic diseases caused by somatic mutations, including rare cases of epilepsy, neurodegeneration, intellectual disability, brain malformations, and autism spectrum … Continue reading

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REPAIRING HEARTS WITH PATCHES OF ENGINEERED TISSUE AT U OF PENN: Raymond Rupert MD, MBA.

A patch for a broken heart is an approach to repairing damaged hearts. A heart attack destroys cardiac muscle, resulting in a fibrotic scar. Weinberger et al. created a living patch for injured hearts using endothelial and cardiac cells grown … Continue reading

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