What’s the importance of studying T cell exhaustion? These so-called exhausted T cells seem to be one of the main reasons patients can’t get rid of their cancer or clear their infection. T cell exhaustion seems to be a problem not only in natural T cells but also engineered CAR-T cells. Therapeutic CAR-T cells seem to […] Read More
Dr Toby Cosgrove, CEO of the Cleveland Clinic, kicked off the 2016 Medical Innovation Summit. This was a very significant meeting organized by the Cleveland Clinic to discuss the transformation of health systems. Dr Cosgrove then introduced Vice President Joe Biden who has a personal interest in and commitment to transforming healthcare. Joe Biden’s son […] Read More
The workplace can be a toxic environment. Especially with the erosion of civility and civil discourse. Because of this toxicity, employees are missing days at work or on short term disability for “stress leave”. Some of these employees may even go on long term disability for mental health problems. With mental health becoming less stigmatized, both […] Read More
New research shows that during inflammation, macrophages convert mitochondria to toxic compound producers that further amplify inflammation. Controlling inflammation can have huge implications when it comes to the treatment of numerous diseases. Efforts to understand and control inflammation are complex and ongoing. Interestingly, breaking research discovered how macrophages play a role in turning mitochondria into […] Read More
The promise that one tier healthcare would be the only option for Canadians has been broken. The evidence of two tier exists in a number of areas across Canada. We will not have to wait for Dr Brian Day’s trial to end in support of the private healthcare option for Canadians. Because two tier in […] Read More
What I Learned From a Stroke at 26: Make Time to Untangle By JONAS KOFFLER New York Times Sept. 24, 2016
As an idealistic, knowledge-hungry college graduate and aspiring writer, I had grown tired of hopping from one office gig to the next. It was 2000 and technology was in full bloom. I wanted to cash in on the digital gold rush. Like many of my friends in Austin, Tex., I figured, why not join the […] Read More
IMMUNOTHERAPY FOR ALZHEIMERS: EXCITING NEW CLINICAL TRIAL- Raymond Rupert MD, MBA. Rupert Case Management Inc.
U of T neurology professor Sandra Black is cautiously optimistic around positive results of a new Alzheimer’s drug reported last week in the high impact journal Nature. “It’s close to being very promising and potentially very exciting,” Black, a senior scientist at Sunnybrook Health Sciences Centre, told the Toronto Star, noting that Sunnybrook is a clinic site for […] Read More
The 311 medicines in development for patients with autoimmune diseases use exciting new approaches aided by the growing scientific understanding of many of these diseases. In addition, medicines already approved to treat one autoimmune disease are being studied for applicability in treating additional diseases. Some of the medicines in the pipeline for autoimmune diseases […] Read More
Advances such as the new stroke clot buster technology provides immediate solutions for patients with ischemic strokes caused by blocked arteries. The outcomes can be exceptional for those lucky enough to have access to his procedure. Case Study: Igor has been successfully teaching the Alexander technique of posture training to dancers and mere mortals with […] Read More
www.puregenomics.com The mapping of the human genome brought tremendous opportunities for optimizing human health, but this flood of information has also led to more questions. Can genetic variations lead to long-term health consequences? How can these be bypassed? And, how can clinicians use genetic information to help people achieve their best health? The expanding field […] Read More
Pediatrics group recommends not using nasal flu vaccine this year The American Academy of Pediatrics isn’t recommending the nasal flu vaccine this year, after a CDC advisory committee determined it didn’t protect against specific flu strains that were most prominent in the past three years. The mist’s effectiveness among kids ages 2 to 17 was […] Read More
Predicting whether cancer patients will respond to chemo: GENOMIC INSTABILITY is the indicator. STAT News. Raymond Rupert MD, MBA.
BREAST CANCER CELLS UP CLOSE. (NATIONAL CANCER INSTITUTE/MASSEY CANCER CENTER AT VIRGINIA COMMONWEALTH UNIV.) Determining whether a particular cancer patient is likely to respond to radiation or chemotherapy is an exceedingly difficult business, and scientists are working to make the decision more clear. They’ve pinpointed a potential way to predict a cancer patient’s prognosis, and one […] Read More
Functional MRI has been used to show which part of the brain lights up and is functioning when we do certain things like talk, imagine, speak etc. Functional MRI has been the basis for thousands of scientific articles. There is a whole science built up around functional MRI. However a recent study in the Proceedings […] Read More
The interactions between T cells and the microbiome (gut bacteria) seemed to influence the fate of the T cells which are an important component of the immune system. The gut microbiome plays a key role in helping the immune system’s T cells mature, according to a new study published in Science Immunology. Researchers examining the […] Read More
What should a patient do when he/she, possibly, needs a lung transplant and can’t get access? CASE STUDY: Terry is a 65 year old male, living in Charlottetown PEI. He was diagnosed with progressive interstitial lung disease. A recent CT lung study showed progression of the lung disease. There was a need for a definitive […] Read More
Health systems in developed countries face a twofold challenge: ensuring financial sustainability and improving quality. Digital strategies and digital transformation can help health systems achieve both these objectives and unlock substantial value through lower spending and superior healthcare delivery. Rising costs, uneven quality Healthcare is claiming an ever-increasing share of national wealth. In recent years, […] Read More
COST RELATED NON-ADHERENCE HURTS PATIENTS: U.S. Value Based Insurance Design to the Rescue- Raymond Rupert MD, MBA.
A robust and growing body of peer-reviewed evidence demonstrates that cost related non-adherence (CRN) exists among Medicare beneficiaries for high-value medical services across the spectrum of clinical care, including preventive screenings, clinician visits, and prescription medication use. This sub-optimal use of evidence-based services results in negative clinical outcomes, increased disparities, and, in some clinical scenarios, […] Read More
The rumour is that Canadians are purchasing about $700,000,000 of healthcare services in the US. A small percentage of the $200B spent each year on healthcare services in Canada. But the number is material and growing. Furthermore, many Canadians are buying healthcare insurance that delivers the services in the US. Best Doctors insurance in Canada […] Read More
Large employers are expecting healthcare costs to remain steady going into 2017, but many are looking to take a number of cost-controlling measures to combat increasing specialty pharma costs. “Controlling health benefits costs remain a high priority for large employers,” says Brian Marcotte, president and CEO of the National Business Group on Health. “While employers […] Read More
The need to renew existing healthcare infrastructure is acute, and doing so will be expensive. Once an asset—whether it is a road, a bridge or a hospital—degrades beyond a certain point, it enters the “failure zone” in its life cycle (Exhibit 1). The cost to maintain such assets is high, adding further financial pressure. In […] Read More